INSPIRATION WITH LALIT MOHAN SHUKLA: Click Chemistry [ Nobel Prize]

Click Chemistry [ Nobel Prize]

INTRODUCTION The term "click chemistry" was coined by in 1998, and was first fully described by Sharpless, Hartmuth C. Kolb, and M.G. Finn of The Scripps Research Institute in 2001.

"Click Chemistry" is a term that was introduced by K. B. Sharpless in 2001 to describe reactions that are high yielding, wide in scope, create only byproducts that can be removed without chromatography, are stereospecific, simple to perform, and can be conducted in easily removable or benign solvent

BLOGGING IN AUGUST 2022

The click reaction has proven to be very useful for modifying functional biomolecules because of its high chemoselectivity. Biologic oligomers and polymers, such as peptides, nucleic acids, and carbohydrates, have been modified by using the copper-catalyzed azide-alkyne cycloaddition click reaction.

The term "Click Chemistry" was introduced by Barry Sharpless and coworkers in 2001 to describe highly efficient and selective reactions that are mainly based on carbon-hetero bond formations. The term "Click" suggests that the molecules are as easily joined together as mechanical snap fasteners. Sharpless et al.

STOCKHOLM, Oct 5 (Reuters) - Scientists Carolyn Bertozzi, Morten Meldal and Barry Sharpless won the 2022 Nobel Prize in Chemistry on Wednesday for discovering reactions that let molecules snap together to create new compounds and that offer insight into cell biology.

CLICK CHEMISTRY NOBEL PRIZE 2022

Click chemistry is not limited to biological conditions: the concept of a "click" reaction has been used in chemoproteomic, pharmacological, and various biomimetic applications. However, they have been made notably useful in the detection, localization and qualification of biomolecules.

The click reaction has proven to be very useful for modifying functional biomolecules because of its high chemoselectivity. Biologic oligomers and polymers, such as peptides, nucleic acids, and carbohydrates, have been modified by using the copper-catalyzed azide-alkyne cycloaddition click reaction.

The classic click reaction is the copper-catalyzed reaction of an azide with an alkyne to form a 5-membered heteroatom ring: a Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC).